Prion seeding assays

Study prion-induced aggregation events in microplates

Our robust and precise plate readers stand fast and long-term shaking to run fluorescent prion seeding assays

The FLUOstar ® Omega microplate reader offers the best combination of performance and flexibility for all of your life science and R & D applications. In particular, it provides the perfect platform for the measurement of prion seeding assays in a microplate format.

Thanks to its robustness and precision , the FLUOstar Omega was selected by Rocky Mountain Labs, Montana as the reference microplate reader for the development of the RT-QuIC assay, and for numerous peer-reviewed publications.

The FLUOstar Omega is one of the only microplate readers built to withstand the prolonged, high-speed shaking required for prion seeding assays.

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The boxes below lead on to our product for prion seeding assays.

BMG LABTECH microplate reader FLUOstar Omega from the front view

FLUOstar Omega

Filter-based multi-mode microplate reader
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The boxes below lead on to prion seeding related application notes and webinars.

Structure of a human prion protein

Real-time quaking induced conversion assay for prion seeding

Real-Time Quaking Induced Conversion assay for prion seeding with the robust FLUOstar Omega.
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Optimizing sensitivity and specifity in the RT- QUiC assay

Tips and tricks to set up and analyze amyloid seeding assays
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Customer success story

Developing a new diagnostic assay for prion diseases with the FLUOstar Omega at Rocky Mountain Laboratories in Hamilton, Montana.


The RML group used the specific shaking, incubation, and fluorescence reading capabilities of the FLUOstar Omega microplate reader to develop a rapid, sensitive, quantitative and high-throughput prion detection assay called Real-Time Quaking Induced Conversion Assay (RT-QuIC). The RT-QuIC assay takes up to 68 hours, and opens the door to preclinical detection.

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