CLARIOstar Plus

Most flexible Plate Reader for Assay Development

BMG LABTECH microplate reader CLARIOstar Plus from the front view

The new CLARIOstar ® Plus is the latest addition to our family. Our most flexible multi-mode plate reader comes equipped with our patented LVF Monochromators ™, filters, and spectrometer. Flexibility combined with the best sensitivity of its class, and our newly developed Enhanced Dynamic Range technology, make it the ideal reader for assay development.

Microplate reader technologies

More about our technologies
Schematic principle of BMG LABTECH's innovative LVF slides

LVF Monochromators

The revolutionary next-generation monochromator technology with filter-like performance. LVF Monochromators ™ take advantage of Linear Variable Filters (LVF) to separate light into distinct wavelengths and continuously adjustable bandwidths. LVF Monochromators allow for filter-like light transmission and performance, and eliminate the stray light issues found in conventional monochromators. They make the CLARIOstar the most sensitive monochromator-based microplate reader on the market.

Alpha Technology Laser

Excitation lasers significantly improve performance and lower limits of detection, since they yield higher excitation energy at a specific wavelength when compared to xenon lamps.

Both the CLARIOstar and the PHERAstar FSX can be equipped with a laser dedicated to Alpha Technology (AlphaScreen ® , AlphaLISA ® and AlphaPlex TM ) detection. This dedicated laser outperforms any xenon-based light source by specifically exciting donors at 680 nm.

Graph showing the performance of direct optic bottom reading with the PHERAstar FSX multi-mode microplate reader

Direct optic bottom reading

Fluorescent and luminescent detection of adherent cells substantially profits from measurements performed from the bottom of the well. The PHERAstar FSX and the CLARIOstar have a free air optical path to the bottom of the microplate, improving sensitivity and eliminating the need for fiber optics or light guides .


Unlike conventional microplate readers, all BMG LABTECH readers require no displacement or installation of any additional hardware when switching between top and bottom reading modes.

Automation

Automation is a key feature in high-throughput screening. Several BMG LABTECH microplate readers have been successfully integrated into various robotic systems. Since all instruments have the same xy dimensions and plate out / in position, once automation has been designed for one BMG LABTECH reader , the solution will work for all. All plate readers can be controlled through ActiveX or DDE interfaces. Moreover, the ASCII data output is the most versatile in the industry and works with most LIMS and automation platforms.

Open PHERAstar showing pumps for reagent injection

Reagent injectors

Many of today's most popular assays such as enzyme kinetics, calcium flux, and dual luciferase require the ability to monitor a signal during and after the addition of a reagent.
All BMG LABTECH readers, with the exception of the SPECTROstar Nano , can be equipped with up to two built-in reagent injectors. Injectors enable reagent delivery to any plate format from 6 to 384 wells.

Schematic description of incubation and shaking

Incubation and shaking

Shaking and incubation allow users to mix the well content and easily run measurements at elevated temperatures. The incubator controls the air temperature in the measurement chamber from room temperature up to 45 ° C or 65 ° C. BMG LABTECH microplate readers are equipped with orbital, double-orbital or linear shaking with definable intensity, duration and direction of motion. These features are available on all BMG LABTECH plate readers.

Schematic description of a BMG LABTECH UV/vis spectrometer

UV / vis spectrometer

BMG LABTECH was the first and is the only microplate reader manufacturer to equip its instruments with a UV / vis spectrometer for absorbance measurements. Similar to a monochromator, but much faster, the spectrometer will capture full-absorbance spectra from 220 to 1000 nm at a resolution of 1 nm in less than one second / well. Alternatively, up to eight discrete wavelengths can be collected at the same time.

Logo for dedicated luminescence ready

Dedicated high performance luminescence

For the optimization of luminescence assays, BMG LABTECH has created an internal dedicated detection system. This allows for a much higher signal-to-noise ratio than in competing readers and for lower limits of detection. Moreover, specific proprietary luminescence optics increase the signal in various plate formats (96, 384, or 1536), allowing for an uncompromised signal regardless of your plate format.

Schematic principle of the z-height focus feature of BMG LABTECH's microplate readers

Z-height focus

Automatic Z-height adjustment is extremely important for obtaining the best possible signal from every sample. If the focus is inaccurate by as little as 0.2 mm, this can result in a signal degradation of up to 25%. BMG LABTECH's Z-height focus adjustment tool scans the whole sample with 0.1 mm resolution and determines the height at which the strongest signal can be measured.

Enhanced Dynamic Range

Enhanced Dynamic Range

Sample signals often span over a wide range of intensities. This makes detection of all samples in a single run problematic as a fixed gain ensures that only a limited range of intensities is reliably detected. Enhanced Dynamic Range was specifically designed to offer the largest possible dynamic range-8 concentration decades. It allows measurement of bright and dim signals in the same run – no gain setting required – and provides highly reliable results over a large dynamic range with no manual intervention.

CLARIOstar Plus

  • Optional Accessories

For more performance: Accessories for CLARIOstar Plus

  • Microplate reader accessories Atmospheric Control Unit (ACU) from the front view

    Atmospheric Control Unit

    Enhanced cell-based assays
  • Microplate reader accessories LVis plate from the front view

    LVis Plate

    Low-volume measurements
  • Microplate stacker directed to the left with CLARIOstar in the background

    Microplate Stacker

    Microplate handling system
  • Microplate reader accessories microplate shaker and incubator THERMOstar opened and from the front view

    THERMOstar

    Intelligent microplate incubation
  • Microplate reader accessories evaluation plate from the front view

    Evaluation Plate

    Functional Microplate Reader Validation
  • Microplate Reader Accessories Filter

    Filters

    Filters for a wide range of applications

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